Parkinson's is a progressive neurodegenerative disease of the brain (loss of brain cells). Normally, there are brain cells that produce dopamine in certain regions of the human brain. These cells are located in a specific area of the brain called the substabynia nigra. Dopamine is a chemical that transmits messages between the substantia nigra and other brain regions that control body movements. With dopamine, people can have flowing. Perform harmonious movements. When 60-80% of the dopamine-producing cells die, not enough dopamine can be produced, and thus the sensory symptoms of Parkinson's disease occur.
The earliest symptoms of Parkinson's disease occur in the enteric nervous system, lower brainstem, and olfactory pathways. Parkinson's disease spreads from these regions to the upper parts of the brain, i.e. to the substanisia nigra and the brain shell. Symptoms such as loss or reduction of smell, sleep disturbances, constipation, tremors and slowing of movements are thought to begin years before the motor symptoms of the disease, so efforts are made to detect these non-motor symptoms as early as possible to halt the progression of the disease.
Sympthoms of the disease:
The symptoms of Parkinson's disease can be divided into two groups: movement-related and non-movement-related (motor and non-motor).
– Motor symptoms include tremor, slowed movement (bradykinesia) and contraction of muscles, inability to move (akinesia), contraction of limbs, inconsistent walking, and hunching over.
– Non-motor symptoms include sleep disturbances, constipation, loss of sense of smell, depression, sexual organ dysfunction, and anxiety. Parkinson's disease is different for each patient. Also occurs differently in each patient. Symptoms can occur at any age, but Parkinson's disease occurs on average around age 60. Age on. It is rarely seen in people under 30.
Genetic reasons are decisive in the early-onset disease. Symptoms of the disease can vary from person to person, and therefore the progression of symptoms also differs. One of the first symptoms that usually occurs is a slowing of the movements of one hand, and the movement of the arm while walking may be minimized. It is accompanied by shoulder pain. Many people experience mild tremors at first. Shaking noticeable during the resting phase. Hands usually tremble, but arms and legs are also affected. However, about 15% of Parkinson's patients do not experience tremor during the course of the disease. As a rule, the symptoms occur unilaterally. When the dominant side of the body is affected, symptoms are most noticeable in some common procedures such as z.B. noticeable when writing. People with tremor and whose symptoms affect the dominant part of the body can be diagnosed earlier and start treatment earlier.
People in the early stages of Parkinson's disease may also have problems with balance, z.B. they may lose their balance when standing, or have difficulty turning around or making sudden movements. Parkinson's patients typically use fewer facial expressions and speak slowly. Non-motor symptoms such as sleep disturbances, depression and anxiety often occur before motor symptoms.
There are no specific tests to clearly identify this disease; Parkinson's disease is diagnosed after the elimination of other diseases with the same symptoms or when the patient responds to Parkinson's medications.
Here is a list of symptoms to watch for:
– Change in facial expression (fixed gaze, no blinking) – The swinging of the arm on one side when walking becomes less – Leaning of the body forward (hunched posture) – Rigid shoulder and shoulder pain – Movement disorders of one leg – Numbness, tingling, pain or discomfort in the neck or limbs – The voice becomes softer – A feeling of inner trembling
The most important thing in diagnosing Parkinson's is that two of the four main symptoms must be present in the patient for some time for a neurologist to diagnose the disease.
Four main motor symptoms:
1. Tremor or tremor 2. Slowed movements, also known as bradikinesia 3. Muscle tension or stiffness in the arms, legs or body 4. Balance problems and possible falls are also known as pstural instability.
Treatment option with stem cells
Stem cells have the ability, when they touch damaged brain cells, to transform into these cells and are therefore used to treat Parkinson's disease. It also treats damaged nerves and muscles. In this way, the progression of the disease is slowed, it may be completely inhibited or regressed. The success rate of treatment depends directly on the age and condition of the patient and the duration of the disease. If the disease is very advanced, more than one treatment may be needed. The number of cells to be delivered depends on age. Patient's weight dependent. Treatment is carried out using either mesenchymal stem cells (derived from the patient's own fatty tie or bone marrow) or fetal stem cells. Which treatment is given depends on the patient's condition. It can be performed in 3 sessions 45 days apart or in 3 consecutive days. During intravenous administration, a specific injection amount can be injected into the vascular vessel leading to the brain.
Depending on the patient's condition, treatment can be tailored specifically for each patient.
Success rates of treatments
Stem cells are small enough to pass through brain cells. For this reason, the success rate of treatment in early diagnosis increases significantly. In the studies conducted, stem cell therapy achieved very high positive results. Progression of the disease was prevented in 74% of patients. The current bad situation has improved.